Get an insight into Biochemistry with Kings’ FMGE coaching classes
Enroll in Kings International Medical Academy's FMGE coaching classes and elevate your preparation for the Foreign Medical Graduate Examination (FMGE). With our comprehensive curriculum and experienced faculty, we provide targeted guidance to help you succeed in this crucial exam. Our interactive teaching methods, combined with personalized attention, ensure a deep understanding of the subjects and enhance your problem-solving skills. Join Kings International Medical Academy's FMGE coaching classes to boost your confidence and increase your chances of clearing the exam with flying colours. In this blog, let's learn more about the topic of biochemistry, which is handled by our esteemed faculty member, Dr. V.S. Kumar. Today, let's focus on the topic ‘Collagen’.
Collagen
1) Most abundant protein in the body
2) Major structural protein in ECM
Components:
Glycine residue, -OH proline & OH-lysine
Gly-x-y repeat
Synthesis:
Endoplasmic recticulum of fibroblast
Stage 1:
Formation of α-chains → Combine → Pre-pro-collagen
Stage 2:
Hydroxylation of Proline & Lusine
Glycosylation to OH- Lysine
Intracellular event- convert → Pre-pro-collagen → Procollagen
Extracellular event
Stage: Tropocollagen is formed
Types:
Type 1: Skin & bONE
Type 2: CarTWOlage
Type 3: ArTHREE
Type 4: Basemnet membrane floor
Disorders of Collagen:
Type 1:
Type 2:
Chondrodysplasia
Osteoarthritis
Type 3:
EDS
Type 4:
Good Pasteurs & Alports Syndrome
Scurvy → ATP-7x mutation
Menkes kinky hairs disease
Wilson’s (ATP-7B mutation)