Enroll now in the ongoing Dermatology classes for FMGE 2023 at Kings
Kings International Medical Academy is currently conducting comprehensive FMGE coaching classes, with a particular focus on dermatology as the exam date approaches. Dr. Akhilesh, an esteemed faculty member, is currently teaching the intriguing topic of Intra-epidermal pathology. Let's delve into this subject and expand our knowledge today.
Intra-Epidermal Pathology
Desmosome Protein
Defect Types
Dg - Desmoglein - Pemphigus
Dp - Desmoplakin - Paraneoplastic pemphigus
Dc - Desmocollin - Subcorneal pustular dermatosis
- Darier's disease
- Hailey-Hailey disease
Melanocyte
Color depends on:
1. Melanosome transfer
2. Melanogenesis
3. Melanosome formation
Never depends on number of Melanocytes → constant / cm² skin
Hypo-pigmentation
↓ ↓ ↓
Melanin Melanocyte Transfer of Melanosome
↓ ↓ ↓
Albinism Vitiligo Nevus Achromicus
↓
Piebaldism
Hyper-Pigmentation
↓
Melanin
↓
Freckle, Melasma
Fitzpatrick → Father of Modern-Derma
Classification:
Skin- colour – 6 types
1- White – always burn, never tans
2
3 ↓
4
5- Indian
6- Negro – always tan, never burn
EBM (Epidermal Basement Membrane)
Dermis-
MC cells – Fibroblast
MC type – Collagen – I (skin)
EMB aka DEJ (Dermo-epidermal Junction)
↓
Hemidesmosome
Lamina Lucida → Laminin
Lamina Densa → Collgen
Sub Lamina → Collgen – Seven
Dermis-
Defect in DEJ – Sub-Epidermal Bullae
BP – Ag – 1 → Bullous Pemphigoid
Dermatitis Herpetiformis
BP - Ag – 2 → Bullous Pemphigoid (2>1)
Pemphigus gestationis
Linear IgA Disease
Collagen- 17 – Epidermolysis Bullosu Junction
5 + 2 + 10 = 17
Collagen- 7 - Epidermolysis Bullosu Dystrophic
17-10=7